RECENT AND UPCOMING (SUBMITTED) PUBLICATIONS

New Standards in Fibrosis Quantification: the Value of Label-free Second Harmonic Generation. Li Chen, Mathieu Petitjean at the Anti-fibrotic Drug Development Forum, November 13-14, 2017, Boston USA 

See poster here

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis (NASH). Jonathan D Roth, Michael Feigh, Sanne S Veidal, Louise K D Fensholdt, Kristoffer T G Rigbolt, Henrik H Hansen, Li C Chen, Mathieu Petitjean, Weslyn W Friley, Niels Vrang, Jacob Jelsing and Mark Young. 

Submitted (10/25) to World Journal of Gastroenterology

Detailed Analysis of the Antifibrotic effect of INT-767, a dual FXR/TGR5 agonist in an obese mouse model of diet-induced and biopsy-confirmed NASH. Sanne Skovgård Veidal, Michael Feigh, Henrik B Hansen, Jacob Jelsing, Niels Vrang, Mathieu Petitjean, Li Chen, Mark Young, Jonathan Roth presented at AASLD 2017, October 20-23 , 2017.

See poster here (Presidential Award)

Novel Methods in Imaging and Quantification of Skeletal Muscle Fibrosis Associated with Severe Muscular Dystrophy. David W. Hammers, Coar C. Coker, Li Chen, Matt Petitjean, Elizabeth R.  Barton, H.Lee Sweeney presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

See poster picture here (poster PDF file to come)

Use of Second Harmonic Generation (SHG) and 2-Photon Emission Imaging to Quantify and Describe the Structure of Tissue Fibrosis in the Rat TNBS intestinal fibrosis model. Laura Johnson, Li.Chen, P. Higgings et all. Poster #2008 presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

Poster Here

Concurrent Semi-Automated Quantification of Liver Fibrosis and Fat Using Label-free Second Harmonic Generation Imaging in Animal Models. M. Petitjean, J. Schwartz, Li Chen. Poster #3003 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017

Poster Here

Quantification of Septa in Liver Fibrosis using Second Harmonic Generation Imaging. Li Chen, Mohammad Naser,  et all. Poster #1016 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017

Poster Here

Systematic Quantification of Histologic Patterns Shows Accuracy in Reflecting Cirrhotic Remodeling (qCP index). Yan Wang et All. doi: 10.1111/jgh.13722

Poster Here

Comparative efficacy of INT-767 vs. Liraglutide in Gubra AMLN Mice. Jonathan Roth et All. Intercept Pharmaceuticals. Keystone Symposia Workshop: approaches to NASH Treatment, March 7th 2017.

Paper Here

Dual Photon Microscopy Based Quantification of Fibrosis-related parameters (q-FP) to Model Disease Progression in Steatohepatitis (NASH). Yan Wang et all. Journal of Hepatology, 10.1002/hep.29090

Paper here

Automated evaluation of liver fibrosis in CCl4, BDL and TAA rodent models using Second Harmonic Generation / Two Photon excited fluorescence microscopy. Feng Liu et al. Laboratory Investigation (2016) , 1-9. 2016 USCAP

Paper here

New Classification of Liver Biopsy Assessment for Fibrosis in Chronic Hepatitis B Patients Before and After Treatment. Yameng Sun et all. Journal of Hepatology, doi: 10.1002/hep.29009

Paper here

Second Harmonic Generation microscopy: a novel automated method for quantification of hepatic steatosis in chronic liver disease. George B. Goh, Wei Qiang Leow, Shen Liang, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Jason P. Chang Poster # 1518 at AASLD 2016.

Read the poster here 

Development and validation of an automated optical imaging system to differentiate severity of hepatitis B- and non-alcoholic steatohepatitis-related fibrosis in patients with concomitant disease. Jason P. Chang, George B. Goh, Wei Qiang Leow, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Poster # 407 at AASLC 2016.

Read the poster here (soon)

Objective quantitative evaluation of anti-fibrotic agents in animal models. Kenneth Zhang, Li Chen, Bertha Xue, Chen Hu, Laurent Gole, and Chuan-Chu Chou. Poster # 69 at The First International Conference on Tissue Repair, Regeneration , and Fibrosis, September 21-25, 2016

See the Poster presentation here.

Stain-free detection and quantification of Bone Marrow Fibrosis using two-photon excitation and second harmonic generation microscopy. Leslie R. Rowe, Ali etman, Jessica Kohan, Josef Prchat, Gideon Ho, Dean Tai, Dong Quan Liu, Mohamed E. Salma at the 2015 US CAP Annual Conference, Poster #287 

Read the poster here

Digital Whole Slide Imaging and Two Photon Microscopy for Liver Fibrosis Scoring and Quantification. Jolanta Jedrzkiewicz, Mary P Bronner, Erinn Downs-Kelly, Jessica Kohan1, Leslie Rowe, Dean Tai, and Mohamed Salama at the 2015 US CAP Annual Conference, Poster #287 

Read the poster here

Automated biphasic morphological assessment of hepatitis B-related liver fibrosis using second harmonic generation microscopy (N=175). Tong-Hong Wang, Tse-Ching Chen, Xiao Teng, Kung-Hao Liang & Chau-Ting Yeh. www.nature.com/scientificreports.  5:12962 | DOI : 10.1038/srep12962   

Read the article here.

qFibrosis: A fully-quantitative innovative method incorporating histological features to facilitate accurate fibrosis scoring in animal model and chronic hepatitis B patients. Shuoyu Xu, Yan Wang, Dean C.S. Tai, Shi Wang, Chee Leong Cheng, Qiwen Peng, Jie Yan, Yongpeng Chen, Jian Sun, Xieer Liang, Youfu Zhu, Jagath C. Rajapakse, Roy E. Welsch, Peter T.C. So, Aileen Wee, Jinlin Hou, Hanry Yu. Journal of Hepatology 2014 vol. 61 pages 260–269

Read the article here.

Fibro-C-Index: comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy. Dean C.S. Tai, Nancy Tan, Shuoyu Xu, Chiang Huen Kang, Ser Mien Chia, Chee Leong Cheng, Aileen Wee, Chiang Li Wei, Anju Mythreyi Raja, Guangfa Xiao, Shi Chang, Jagath C. Rajapakse. Journal of Biomedical Optics 14(4), 0440103 (July/August 2009)

Read the article here.

Nonlinear optical microscopy: use of second harmonic generation and two-photon microscopy for automated quantitative liver fibrosis studies. Sun W1, Chang S, Tai DC, Tan N, Xiao G, Tang H, Yu H. Journal of Biomedical Optics 13(6), 064010 (November/December 2008)

Read the article here.

 

Light-CT Scanner

Modified full-field optical coherence tomography: A novel tool for rapid histology of tissues. Manu Jain, Nidhi Shukla, Maryem Manzoor, Sylvie Nadolny, Sushmita Mukherjee. Journal of Pathology Informatics 2011; 2:28.

Read the article here.

Fibrosis impacts human adipocyte functions through mechanical cues. Pellegrinelli V, Heuvingh J, du Roure O, Rouault C, Devulder A, Klein C, Lacasa M, Clément E, Lacasa D and Clément K. Journal of Pathology 2014 Jun;233(2):183-95

Read the article here.